冀立霞, 博士，教授，硕士研究生导师

工作和学习经历

2025.01-至今 太阳集团官网 suncitygroup太阳集团  教授

2017.03-2024.12 太阳集团官网 suncitygroup太阳集团，副教授

2015.08-2017.12 中国第24批援坦桑尼亚医疗队坦桑尼亚MUHAS大学客座教授

2009.11-2017.02太阳集团官网 suncitygroup太阳集团，讲师

2006.09-2009.07 中国医学科学院&北京协和医学院药物研究所药理学专业，博士

2003.09-2006.07 山东第二医科大学 药理学专业，硕士

1998.09-2003.07 山东第二医科大学 临床医学专业，本科

主要研究方向：

1. 妊娠期糖尿病

2. 抗糖尿病药物的研发

一直从事肥胖相关糖尿病的机制研究和药物研发。目前主要关注两点，一是妊娠期糖尿病，重点从子代胰岛及肝脏发育异常的角度探寻妊娠期糖尿病致子代成年后高发代谢性疾病的根源所在；二是抗肥胖相关糖尿病的药物研发，从日常饮食、天然提取物及化合物中筛选能够有效延缓糖尿病进展的有效成分，并进行机制探讨。

主要科研项目(近5年)：

1. 国家自然科学基金面上项目, 妊娠糖尿病脐静脉血外泌体借力PI3K-AktFoxO/mTORC1通路致子代胰岛胚胎期发育成熟异常的研究, 2023-2026, 主持

2. 山东省自然基金面上项目，胰岛固有巨噬细胞在妊娠期糖尿病致子代鼠胰岛发育成熟异常中的研究，2025-2027，主持

3. 国家自然科学基金面上项目, 海绵Stylissa massa靶向醛糖还原酶ALR2的生物碱成分高效发现及作用机制研究, 2023-2026，参与

代表性论文和专著（近5年）：

1. Xinyu Jia, xiangju Cao, Yuan Wang, Lixia Ji*, High-Calorie Diet Exacerbates the Crosstalk Between Gestational Diabetes and Youth-Onset Diabetes in Female Offspring Through Disrupted Estrogen Signaling, Nutrients, 2025,17,2128.

2. Chunxue Xu, Linhai Zou, Li Wang,Xiangju Cao, Xinyu Jia, Yuan Wang, Guohui Jiang, Lixia Ji*, Gestational diabetes mellitus-derived miR-7-19488 targets PIK3R2 mRNA to stimulate the abnormal development and maturation of offspring-islets. Life Sciences 2025, 363: 123369.

3. Linhai Zou , Chunxue Xu, Li Wang, Xiangju Cao, Xinyu Jia, Zhihong Yang, Guohui Jiang, Lixia Ji*. Human gestational diabetes mellitus–derived exosomes impair glucose homeostasis in pregnant mice and stimulate functional maturation of offspring-islets. Life Sciences 2024,342:122514.

4. Ruixin Hu, Linhai Zou, Li Wang, Chunxue Xu, Mengmeng Qi, Zhihong Yang, Guohui Jiang*, Lixia Ji*. Probiotics alleviate maternal metabolic disorders and offspring-islet abnormalities in gestational diabetic mice. Journal of Functional Foods, 2022,99: 105300.

5. Ji Zhou, Xiaoyi Zhang, Lixia Ji*, Guohui Jiang* . Identification of potential biomarkers of type 2 diabetes mellitus related immune infiltration using weighted gene co-expression network analysis, BioMed Research International, 2022: 9920744.

6. Susu Chen, Wenyan Wang, Qilong Cao, Shen Wu, Ningli Wang, Lixia Ji*, Wei Zhu*.Cationic Mechanosensitive Channels Mediate Trabecular Meshwork Responses to Cyclic Mechanical Stretch.Frontiers in Pharmacology. 2022,13:881286.

7. Ruixin Hu, Yanting Yuan, Chaolong Liu, Ji Zhou, Lixia Ji*, Guohui Jiang*. New insights into the links between anti-diabetes drugs and gutmicrobiota. Endocrine Connections. 2021,10: R36–R42.

8. Yanting Yuan, Ji Zhou, Ruixin Hu, Linhai Zou, Lixia Ji*,Guohui Jiang* Piperine protects against pancreatic β-cell dysfunction by alleviating macrophage inflammation in obese mice. Life sciences, 2021, 274: 119312.

9. ChaolongLiu, YantingYuan, JiZhou, RuixinHu, LixiaJi*, GuohuiJiang*. Piperine ameliorates insulin resistance via inhibiting metabolic inflammation in monosodium glutamate-treated obese mice. BMC Endocrine Disorders, 2020.20:152.

联系方式：

电话: 15063930201

邮箱: lixiaji@163.com lixiaji@qdu.edu.cn